Dengue and dengue haemorrhagic fever

Author: Vanessa Ngan, Staff Writer, 2008.

What is dengue and dengue haemorrhagic fever?

Dengue and dengue haemorrhagic fever is a viral illness that is spread from human-to-human by the bite of dengue virus-carrying mosquitoes. It has become the most common arboviral illness (infections caused by viruses transmitted by arthropods such as mosquitoes and ticks) transmitted worldwide, with about two fifths of the world's population now at risk. It is becoming a major public health problem.

Dengue infection causes a severe flu-like illness and is known as dengue fever. Some patients who have suffered dengue fever from one of four serotypes of dengue virus may be re-infected with another dengue serotype and develop a more severe form of dengue fever called dengue haemorrhagic fever. This is a leading cause of serious illness among children in some Asian countries and can lead to dengue shock syndrome, which may cause death.

Zika virus is another flavivirus infection similar to dengue but less severe. It is also transmitted by mosquito bites.

Where does dengue fever come from and how is it spread?

Dengue viruses are small, spherical, single-stranded enveloped RNA viruses belonging to family Flaviviridae, genus Flavivirus. There are four distinct viral sertotypes; dengue virus 1 (DENV-1), dengue virus 2 (DENV-2), dengue virus 3 (DENV-3) and dengue virus 4 (DENV-4). Reports of dengue fever-like illnesses have been reported as far back as 265AD in Chinese medical writings. Nowadays, the virus has spread to more than 100 countries worldwide. Possible factors for dengue fever spread include:

The mosquito Aedes aegypti is the main Aedes species involved in transmitting the dengue virus from infected individuals to healthy contacts. These mosquitoes breed in and around ponds of stagnant water where humans live and usually bite during daylight hours. It is not unusual for entire families who develop infection within a 24- to 36-hour period to have been bitten by a single infected mosquito. When a human is infected the virus circulates the blood for 2-7 days (about the same time they suffer the fever). It is during this time that the Aedes mosquito may acquire the virus, then bite and infect another unsuspecting victim.

Currently the only continents that do not have dengue viral transmission are Europe and Antarctica, as these areas do not have the mosquito population to allow further spread of dengue from infected patients returning from other countries.

What are the signs and symptoms of dengue fever?

At about 24-36 hours after being bitten by a virus-carrying mosquito, patients will experience sudden high fever (as high as 41C). Just before fever develops, many patients experience chills, skin rash and facial flushing. Severe myalgia (muscle pain) of the lower back, arms and legs, and arthralgia (joint pain), especially of the knees and shoulders may also be present. Haemorrhagic symptoms may include small amounts of bleeding from the nose or gums. Other non-specific symptoms may include headache, fatigue, malaise, abdominal pain, sore throat and cough.

Cutaneous manifestations of dengue fever

As dengue fever is emerging as a major public health problem several studies have been conducted on the illness. A recent epidemic in India provided cases for one study that observed 256 “suspect cases” of dengue fever. It investigated the prevalence and type of skin manifestations in dengue viral infection (Thomas et al). Some of their findings are listed below:

What is the treatment of dengue fever?

There is no vaccine or specific treatment available against dengue infection. It is difficult to develop a vaccine because of the 4 different dengue viruses that cause the disease. A suitable vaccine would need to be able to protect against all 4 viruses.

Fortunately, dengue fever is usually self-limiting and resolves with supportive therapy. Paracetamol (acetaminophen) may be used to treat patients with fever. Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are not recommended. Fever that typically begins on the 3rd day after being infected usually lasts 5-7 days. Some patients may experience what is called saddleback fever; this is where fever subsides for a day and then returns. It is during this time that patients are at risk for developing dengue haemorrhagic fever or dengue shock syndrome.

Patients who deteriorate after a few days of fever and develop signs such as dehydration, tachycardia (rapid heart rate), reduced consciousness and drop in blood pressure must be monitored closely and receive appropriate medical treatment to prevent complications of dengue haemorrhagic fever and dengue shock syndrome. Improved recognition and experience with the effects and progression of dengue haemorrhagic fever by medical staff has reduced mortality rates from more than 20% to less than 1%.

How to prevent dengue fever

The best way to prevent dengue fever is by preventing spread of the virus by vector control. This means eliminating or controlling mosquito breeding sites. The dengue virus- carrying mosquito likes to breed in artificial containers and receptacles containing water. The following measures can be taken to reduce the breeding of mosquitoes.

People can do the following to prevent themselves from being bitten by mosquitoes.

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