Electrical impedance spectroscopy for melanoma diagnosis

Author: Anoma Ranaweera B.V. Sc; PhD (Clinical Biochemistry, University of Liverpool, UK). Chief Editor: Dr Amanda Oakley, Dermatologist, Hamilton, New Zealand, June 2014.

Electrical impedance spectroscopy (EIS) is used by a point-of-care portable device called Nevisense™ (Scibase AB, Stockholm, Sweden) to objectively analyse lesions with suspicion of melanoma.

*Images supplied by Scibase

What is electrical impedance spectroscopy?

Visual examination is normally sufficient when identifying most types of skin lesion. However, when it comes to atypical lesions, a clinical diagnosis based on only a visual examination may pose a challenge, leading to unnecessary excisions or even missed malignancies.

Dermatoscopy uses a hand-held skin surface microscope to examine skin lesions. In expert hands increases the chance of correct diagnosis, but requires training and considerable experience.

In spectrometric analysis of skin lesions, a computer software program is used that calculates and extracts information about the cells and structures of the skin. The method uses a light beam that penetrates beneath the skin surface. Light images taken with a digital camera or hand-held scanner are then fed into a computer for detailed analysis.

In electrical impedance spectroscopy, the varying electrical properties of human tissue are used to categorise cellular structures and thereby detect malignancies.

SciBase Electronic Impedance Spectroscopy (EIS), is a patented technology developed at the Karolinska Institute in Stockholm, Sweden.

How does EIS work?

What are the advantages of EIS analysis?

EIS analysis provides unique information that complements the physicians' visual examinations, particularly in cases of cutaneous lesions with unclear clinical signs of melanoma. Benefits include:

Clinical evidence supporting the efficacy of EIS

Clinical use of EIS

Indications for use of EIS

Related information

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