What is necrotising fasciitis?
Necrotising fasciitis is a very serious bacterial infection of the soft tissue and fascia (a sheath of tissue covering the muscle). The bacteria multiply and release toxins and enzymes that result in thrombosis (clotting) in the blood vessels. The result is destruction of the soft tissues and fascia.
The main types of necrotising fasciitis are:
- Type I (polymicrobial i.e. more than one bacteria involved)
- Type II (due to haemolytic group A streptococcus, staphylococci including methicillin resistant strains/MRSA)
- Type III (gas gangrene, eg due to clostridium)
- Other: Marine organisms (vibrio species, Aeromonas hydrophila, considered Type III in some reports) and fungal infections (candida and zygomecetes, type IV in some reports)
Type I necrotising fasciitis
Bacteria causing type 1 necrotising fasciitis include Staphylococcus aureus, Haemophilus, Vibrio and several other aerobic and anaerobic strains (Escherichia coli, Bacteroides fragillis). It is usually seen in the elderly or in patients affected with diabetes or other conditions.
Type II necrotising fasciitis
Type II necrotising fasciitis has been sensationalised in the media and is commonly referred to as flesh-eating disease. It affects all age groups. Healthy people are also prone to infection with this group.
Type II necrotising fasciitis
Type III necrotising fasciitis is caused by Clostridia perfringens or less commonly Clostridia septicum. It usually follows significant injury or surgery and results in gas under the skin: this makes a crackling sound called crepitus. IV drug users injecting “black tar” heroin subcutaneously can also be infected with clostridia and develop necrotising fasciitis.
Necrotising fasciitis due to marine organisms is usually due to contamination of wounds by sea water, cuts by fish fins or stingers, or consumption of raw seafood. It occurs more commonly in patients with liver disorders. These infections can be very serious and can be fatal if not attended within 48 hours.
Fungal necrotising fasciitis complicates traumatic wounds in immunocompromised people.
Other terms used for necrotising fasciitis include haemolytic streptococcal gangrene, Meleney ulcer, acute dermal gangrene, hospital gangrene, suppurative fasciitis, and synergistic necrotising cellulitis.
Necrotising fasciitis affecting perineal, genital and perianal regions is known as Fournier gangrene. This has a particularly high death rate ranging from 15 to 50%.
How do you get necrotising fasciitis?
Necrotising fasciitis may occur in anyone, in fact, almost half of all known cases of streptococcal necrotising fasciitis have occurred in young and previously healthy individuals. The disease may occur if the right set of conditions is present, these include:
- An opening in the skin that allows bacteria to enter the body. This may occur following minor injury (eg small cut, graze, pinprick, injection), or a large wound due to trauma or surgery (eg laparoscopy, sclerotherapy, endoscopic gastrostomy, thoracostomy, caesarean section, hysterectomy). Sometimes no point of entry can be found.
- Cervicofacial necrotising fasciitis can follow mandibular fracture or dental infection.
- Direct contact with a person who is carrying the bacteria or the bacteria is already present elsewhere on the person.
- Particularly invasive strains of bacteria, eg streptococci that evade the immune system and produce a toxin called cysteine protease SpeB, which dissolves tissue.
- In children, type II necrotising fasciitis may complicate chickenpox. Other causes of necrotising fasciitis in chidren include omphalitis, necrotising enterocolitis and urachal anomalies.
Risks for necrotising fasciitis include:
- Aspirin and non-steroidal anti-inflammatory drugs
- Advanced age
- Immune suppression
- Drug abuse
- Severe chronic illness
Pathophysiology of necrotising fasciitis
Infection starts in the superficial fascia. Enzymes and proteins released by the responsible organisms cause necrosis of fascial layers. Horizontal spread of infection may not be clinically apparent on the skin surface and hence diagnosis may be delayed. Infection then spreads vertically up into the skin and down into deeper structures. Thrombosis occludes the arteries and veins leading to ischaemia and necrosis of the tissues.
- M proteins, which initiate an inflammatory response with release of numerous cytokines (L-1, IL-6, TNFα)
- Exotoxins, which destroy neutrophils allowing bacterial growth and destroying tissues.
Aerobic and anaerobic bacteria produce hydrogen, nitrogen, hydrogen sulfide, and methane gases that destroy hyaluronic acid enabling spread of infection.
What are the signs and symptoms of necrotising fasciitis?
Signs and symptoms vary between individuals but often some or all of the following are present.
- The most common site of infection is the lower leg. Necrotising fasciitis may also affect upper limb, perineum, buttocks, trunk, head and neck.
- Symptoms appear usually within 24 hours of a minor injury:
- Pain is often very severe at presentation and worsens over time
- There may be flu-like symptoms, such as nausea, fever, diarrhoea, dizziness and general malaise
- Intense thirst develops as body becomes dehydrated
Symptoms after 3 to 4 days
As necrotising fasciitis takes hold:
- The affected area starts to swell and may show a purplish rash
- Large dark marks form that turn into blisters filled with dark fluid
- Wound starts to die and area becomes blackened (necrosis)
- Oedema is common
- A fine crackling sensation under the skin (crepitus) is due to gas in the tissues
- Severe pain continues until necrosis /gangrene destroys peripheral nervs when the pain subsides.
- Infection may not improve when antibiotics are given
By about days 4-5, the patient is very ill with dangerously low blood pressure and high temperature. The infection has spread into the bloodstream and the body goes into toxic shock. The patient may have altered levels of consciousness or become totally unconscious.
Metastatic abscesses can develop in liver, lung, spleen, brain, pericardium, and rarely, in the skin.
How is necrotising fasciitis diagnosed?
A thorough history and clinical examination are crucial in arriving at the diagnosis of necrotising fasciitis. Special care should be taken when examining immunocompromised patients, as presentation of symptoms/signs may be atypical.
- Clostridial and streptococcal infections as a result of traumatic or surgical wound usually manifest quickly compared to necrotising fasciitis due to other organisms.
- A positive finger test is highly pathognomic for necrotising fasciitis. A 2 cm vertical incision is made in the affected skin and an index finger is pushed into the tissue. The test is positive if the finger passes through the subcutaneous tissue without resistance.
- There is poor adherence of tissue to fascia on incising the site
- Necrotic tissue/pus oozes out of the fascial planes
- Dishwater-coloured fluid seeps out of the skin.
- Typically, necrotising fasciitis does not bleed.
Laboratory screening investigations
These usually show:
- WBC count > 15.4 x 109/L.
- Serum sodium < 135 mmoL
- Raised CRP (> 16 mg/dL)
- Raised CK level (> 600 U/L)
- Urea > 18 mg/dL.
Blood culture, deep tissue biopsy and Gram stain help in identifying the culprit organism(s) and guide the choice of antibiotic. If Staphylococcus aureus is detected, MRSA sensitivity test should be done. Blood cultures are usually negative for clostridial species.
Fungal culture should be performed in immunocompromised and trauma patients.
X-ray, CT and MRI identify areas of fluid collection, inflammation and gas within the soft tissues.
Laboratory risk indicator for necrotising fasciitis
The Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) is a tool that aids in distinguishing necrotising fasciitis from other tissue infections based on six parameters. A score of ≥ 6 favours necrotising fasciitis. Tis test is not appropriate for all cases and is not completely reliable.
CRP (mg/L) ≥150:
- 4 points
WBC count (×103/mm3):
- <15: 0 points
- 15–25: 1 point
- >25: 2 points
- >13.5: 0 points
- 11–13.5: 1 point
- <11: 2 points
Sodium (mmol/L) <135:
- 2 points
Creatinine (umol/L) >141:
- 2 points
Glucose (mmol/L) >10:
- 1 point
What is the treatment for necrotising fasciitis?
Once the diagnosis of necrotising fasciitis is confirmed, treatment should be initiated without delay.
- The patient must be hospitalised and is often admitted to an intensive care unit.
- The causative organism(s) should be identified and treated with high dose intravenous antibiotics. Initial antibiotic choice includes penicillin, clindamycin, metronidazole, cephalosporins, carbapenems, vancomycin and linezolid. After culture is reported, the choice is adjusted.
- It is absolutely vital than an experienced surgeon urgently removes all necrotic tissue (debridement).
- Supplemental oxygen, fluids and medicines may be needed to raise blood pressure.
- Hyperbaric oxygen and intravenous immunoglobulin may also be considered.
Immediate surgical debridement improves survival and avoids comlications of necrotising fasciitis. All the infected tissue should be cleared away using adequate excision. Repeated debridements are carried out for a few days.
When the acute infection has subsided, the wound should be closed with skin grafting if required. Vacuum-assisted wound closing devices may be useful to heal a persistent ulcer.
What is the likely outcome?
Prompt diagnosis and treatment is essential to reducing the risk of death and disfigurement from necrotising fasciitis.
If diagnosed and treated early, most patients will survive necrotising fasciitis with minimal scarring. If there is significant tissue loss, later skin grafting will be necessary and in some patients amputation of limbs is required to prevent death.
Up to 25% of patients will die from necrotising fasciitis, due to complications such as renal failure and septicaemia (blood poisoning) and multiorgan failure.