Author: Amanda Oakley, Dermatologist, Hamilton New Zealand. Updated July 2014.

What is pompholyx?

Pompholyx is a form of hand/foot eczema characterised by vesicles or bullae (blisters). It is a form of vesicular dermatitis of hands and feet, also called vesicular endogenous eczema, and may be the same condition as dyshidrotic eczema. It is sometimes subclassified as cheiropompholyx (hands) and pedopompholyx (feet).

Who gets pompholyx?

Pompholyx most often affects young adults.

What causes pompholyx?

Pompholyx is multifactorial. In many cases it appears to be related to sweating, as flares often occur during hot weather, humid conditions, or following emotional upset. Other contributing factors include:

What are the clinical features of pompholyx?

Pompholyx presents as recurrent crops of deep-seated blisters on the palms and soles. They cause intense itch and/or a burning sensation. The blisters peel off and the skin then appears red, dry and has painful fissures (cracks).

When involving the distal finger adjacent or proximal to the nail fold, it can result in paronychia (nail fold swelling) and nail dystrophy with irregular pitting and ridges.

More images of pompholyx ...

What are the complications of pompholyx?

Secondary bacterial infection with Staphylococcus aureus and/or Streptococcus pyogenes is common in pompholyx, and results in pain, swelling and pustules on the hands and feet.

How is pompholyx diagnosed?

The clinical presentation is typical.

Aggravating factors

As in other forms of hand dermatitis, pompholyx is aggravated by contact with irritants such as water, detergents and solvents. Contact with them must be avoided as much as possible and protective gloves worn to prevent additional irritant contact dermatitis.

People with pompholyx that are found to be allergic to nickel must try to avoid touching nickel items.

What is the treatment for pompholyx?

Pompholyx is challenging to treat. Topical therapy is relatively ineffective because of the thick horny layer of skin of palms and soles.

General measures

Prescription medicines

Other options

What is the outlook for pompholyx?

Pompholyx generally gradually subsides and resolves spontaneously. It may recur in hot weather or after a period of stress, and in some patients is recalcitrant.

Related information

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